Journal article
Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood
Pierre-antoine Dugue, Allison Hodge, Ee Ming Wong, Eric Joo, Chol-Hee Jung, John Hopper, Dallas English, Graham Giles, Roger Milne, Melissa Southey
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS | Published : 2021
Abstract
Abstract Background Prenatal exposure to maternal smoking is detrimental to child health but its association with risk of cancer has seldom been investigated. Maternal smoking induces widespread and long-lasting DNA methylation changes, which we study here for association with risk of cancer in adulthood. Methods Eight prospective case-control studies nested within the Melbourne Collaborative Cohort Study were used to assess associations between maternal-smoking-associated methylation marks in blood and risk of several cancers: breast (N = 406 cases), colorectal (N = 814), ..
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